Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides

• DOI: 10.1021/acs.orglett.8b01520
• Publication Date: 2018-06-11T12:07:34Z
• Authors: Paramita Mukherjee; Cristian P. Woroch; Leah Cleary; Mark Rusznak; Ryan W. Franzese; Matthew R. Reese; Joseph W. Tucker; John M. Humphrey; Sarah M. Etuk; Sabrina C. Kwan; Christopher W. am...; Nicholas D. Ball
• Keywords: Sulfonyl; Sulfonamide

A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts wide array of sterically and electronically diverse into the corresponding sulfonamides in good yield.