Revelation of the Balanol Biosynthetic Pathway in Tolypocladium ophioglossoides

• DOI: 10.1021/acs.orglett.8b01543
• Publication Date: 2018-10-02T17:42:32Z
• Authors: Xian He; Min Zhang; Yuan-Yang Guo; Xu-Ming Mao; Xin-Ai Chen; Yong-Quan Li
• Keywords: Gene cluster

A cryptic gene cluster, bln, was activated by genome mining in Tolypocladium ophioglossoides. This activation led to the production of balanol and eight other metabolites. Gene disruption metabolite profile analysis showed that biosynthesis involved convergence independent PKS NRPS pathways, a biosynthetic pathway for proposed.