Rhodium(III)-Catalyzed Meta-Selective C–H Alkenylation of Phenol Derivatives

• DOI: 10.1021/acs.orglett.8b01995
• Publication Date: 2018-08-20T16:40:50Z
• Authors: Rui-Jie Mi; Yong-Zhen Sun; Jing-Yun Wang; Jing Sun; Zhaoqing Xu; Ming-Dong Zhou
• Keywords: 01 natural sciences; 0104 chemical sciences

Rhodium(III)-catalyzed remote meta-selective-C-H alkenylation of phenol derivatives has been developed using a traceless organosilicon template as the directing group. This transformation proceeds smoothly with good yields and high meta-selectivities toward a series of phenol and alkene substrates. In addition, this protocol provides an effective strategy for late-stage transformations of various meta-alkenylated aromatic compounds.