Eucalyptusdimers A–C, Dimeric Phloroglucinol–Phellandrene Meroterpenoids from Eucalyptus robusta

• DOI: 10.1021/acs.orglett.8b02259
• Publication Date: 2018-08-08T16:27:14Z
• Authors: Xu-Jie Qin; Mi-Yan Feng; Hui Liu; Wei Ni; Tyler Rauwolf; John A. Porco; Huan Yan; Li He; Hai-Yang Liu
• Keywords: Chemistry; Eucalyptus; Chemical sciences; organic; Organic chemistry; 500; 01 natural sciences; 0104 chemical sciences

Eucalyptusdimers A-C, three dimeric phellandrene-derived meroterpenoids featuring an unprecedented, fused skeleton between two phellandrene and two acylphloroglucinol subunits, along with one biogenetically related intermediate, (±)-eucalyprobusone A, were isolated from the fruits of Eucalyptus robusta. Their structures and absolute configurations were elucidated using spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. The isolated meroterpenoids were evaluated for their anti-inflammatory, acetylcholinesterase inhibitory, and protein tyrosine phosphatase 1B inhibitory effects.