N,N′-Di(acylamino)-2,5-diketopiperazines: Strategic Incorporation of Reciprocal n → π* Interactions in a Druglike Scaffold

• DOI: 10.1021/acs.orglett.8b02449
• Publication Date: 2018-08-30T04:05:17Z
• Authors: Abdur Rahim; Biswajit Sahariah; Bani Kanta Sarma
• Keywords: Diketopiperazines; Reciprocal

The incorporation of the recently discovered reciprocal n → π* interactions in 2,5-diketopiperazines (DKPs) is reported to design a novel N, N'-di(acylamino)-2,5-diketopiperazine (daa-DKP) scaffold. design, synthesis, and structural features daa-DKPs effect their rigidity discussed.