Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone

• DOI: 10.1021/acs.orglett.8b02750
• Publication Date: 2018-10-10T20:02:48Z
• Authors: Bo Zhou; Zhuo Wu; Ding Ma; Xiaoming Ji; Yanghui Zhang
• Keywords: Component (thermodynamics)

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. provides an innovative synthetic approach for indoles. features high efficiency, broad substrate scope, excellent regioselectivity. C,C-Palladacycles should act as the intermediates. C,C-palladacycles are obtained from simple halides alkynes then reacted with to afford