Base-Mediated Direct Transformation of N-Propargylamines into 2,3,5-Trisubstituted 1H-Pyrroles

• DOI: 10.1021/acs.orglett.8b03112
• Publication Date: 2018-11-08T12:55:12Z
• Authors: Pawan K. Mishra; Shalini Verma; Manoj Kumar; Akhilesh K. Verma
• Keywords: 2. Zero hunger; 01 natural sciences; 0104 chemical sciences; 3. Good health

An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis of structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable and is tolerated by a variety of functional groups. Key intermediates of natural product discoipyrrole C as well as HMG-CoA-reductase inhibitor have been successfully synthesized using developed chemistry. The proposed mechanism was supported by control experiments.