Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes

• DOI: 10.1021/acs.orglett.8b03492
• Publication Date: 2018-12-19T12:57:12Z
• Authors: Anqi Huang; Lili Zhang; Dongmei Li; Yidong Liu; Hailong Yan; Wenjun Li
• Keywords: Stereocenter; Chirality; Axial Chirality; Asymmetric carbon; Carbon fibers; Stereoisomerism

An organocatalytic enantioselective method for the synthesis of multiple stereoisomers bearing E, Z configurations, stereogenic carbon centers, and axially chiral styrenes is reported. The enabled rapid construction a series stereochemical complexity products with excellent selectivity, diastereoselectivity (>20:1 dr), enantioselectivity (up to 96% ee). This provides an efficient concise route wide range potential applications in organic synthesis.