Expeditious Synthesis of Isoquinolone Derivatives by Rhodium(I)-Catalyzed Annulation Reaction through C–C Bond Cleavage

• DOI: 10.1021/acs.orglett.8b03653
• Publication Date: 2018-12-14T18:34:06Z
• Authors: Yiyi He; Chengsha Yuan; Zeqi Jiang; Li Shuai; Qing Xiao
• Keywords: Annulation; Cleavage (geology); Bond cleavage

A Rh(I)-catalyzed intermolecular cyclization between isocyanates and benzocyclobutenols leading to isoquinolin-1(2 H)-ones through selective cleavage of a C-C bond has been realized. Exploiting the same strategy, we developed three-component reaction benzocyclobutenols, isonitriles, sulfonyl azides access H)-imines. These procedures provide unique expeditious isoquinolone derivatives which are otherwise difficult prepare in satisfactory yields with excellent functional-group tolerance under mild conditions.