Copper-Catalyzed C4-H Regioselective Phosphorylation/Trifluoromethylation of Free 1-Naphthylamines

• DOI: 10.1021/acs.orglett.8b03768
• Publication Date: 2019-01-02T13:04:05Z
• Authors: Chunfeng Jing; Xiaolan Chen; Kai Sun; Yongkang Yang; Tong Chen; Yan Liu; Lingbo Qu; Yufen Zhao; Bing Yu
• Keywords: Trifluoromethylation

A novel and facile copper-catalyzed synthetic methodology was developed to access a large variety of 4-phosphoryl-substituted 1-naphthylamines by reacting various with different diarylphosphine oxides in the presence Cu(OAc)2 Ag2CO3 one pot under mild reaction conditions. This system also suitable for being employed synthesize 4-trifluoromethyl-substituted Togni's reagent CuI NaOAc DMSO