Urceoloids A and B, Two C19 Steroids with a Rearranged Spirocyclic Carbon Skeleton from Urceola quintaretii

• DOI: 10.1021/acs.orglett.9b00539
• Publication Date: 2019-03-05T20:59:41Z
• Authors: Yu-Hao Ren; Qun-Fang Liu; Li Chen; Shi-Jun He; Jian-Ping Zuo; Yao-Yue Fan; Jian-Min Yue
• Keywords: Carbon skeleton; Skeleton (computer programming); Carbon fibers

Urceoloids A (1) and B (2), two C19 steroids with a rearranged new carbon skeleton by featuring very unique spiro[4.4]nona-3,6,8-triene system, biosynthetically related known steroid (3) were isolated from Urceola quintaretii. Their structures completely established combined method. plausible biosynthetic pathway for the represented compounds 1 2 was proposed. Compounds 3 showed immunosuppressive activities.