Dual Directing-Groups-Assisted Redox-Neutral Annulation and Ring Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C–H/C–C Activations

• DOI: 10.1021/acs.orglett.9b00812
• Publication Date: 2019-03-27T22:54:56Z
• Authors: Jin-Long Pan; Chang Liu; Chao Chen; Tuan-Qing Liu; Man Wang; Zhenliang Sun; Shu-Yu Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

A cascade [3 + 2] annulation and ring opening of N-aryloxyacetamides with 1-alkynylcyclobutanols via Rh(III)-catalyzed redox-neutral C-H/C-C activations using internal oxidative O-NHAc and -OH as the dual directing groups has been achieved. This reaction provided an efficient and regioselective approach to benzofuran derivatives with good functional group compatibility and high yields.