General Oxidative Aryl C–P Bond Formation through Palladium-Catalyzed Decarbonylative Coupling of Aroylhydrazides with P(O)H Compounds

• DOI: 10.1021/acs.orglett.9b00922
• Publication Date: 2019-04-18T13:24:23Z
• Authors: Jianyu Dong; Long Liu; Xuyu Ji; Qian Shang; Lixin Liu; Lebin Su; Bing Chen; Ruifeng Kan; Yongbo Zhou; Shuang-Feng Yin; Li-Biao Han
• Keywords: 01 natural sciences; 0104 chemical sciences

Oxidative C-C/P-H cross-coupling is achieved via Pd-catalyzed decarbonylative cross-coupling of aroylhydrazides with P(O)H compounds. The unique cooperative reaction system, especially the Brønsted acid and bidentate phosphine ligand, allows the selective activation of the inert C-C bond and the suppression of the undesired oxidation and coordination of >P(O)-H compounds, leading to a general oxidative synthesis of aryl phosphorus compounds from easily available substrates.