Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A–E from the Wrinkled Peach Mushroom, Rhodotus palmatus

• DOI: 10.1021/acs.orglett.9b01017
• Publication Date: 2019-04-22T13:05:16Z
• Authors: Birthe Sandargo; Maira Michehl; Dimas Praditya; Eike Steinmann; Marc Stadler; Frank Surup
• Keywords: Molecular Structure; Cell Survival; Terpenes; Basidiomycota; Hepacivirus; Antiviral Agents; 01 natural sciences; Cell Line; 0104 chemical sciences; 3. Good health; Humans; Spiro Compounds; Sesquiterpenes

Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.