Copper-Catalyzed Asymmetric Propargylation of Indolizines

• DOI: 10.1021/acs.orglett.9b03032
• Publication Date: 2019-10-23T18:29:01Z
• Authors: Lei Yang; Xiang Pu; Dawen Niu; Zhengyan Fu; Xia Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

Methods to diversify indolizines are valuable for the discovery of medications and fluorescent molecules. The utilization of copper-catalyzed asymmetric propargylation to install a terminal alkyne handle on indolizine heterocycle is reported. This method delivers C3-propargylation products from C2-substituted indolizines or C1-propargylation products from C2,C3-disubstituted indolizines through a stereoconvergent pathway.