Peptoid-Based Programmable 2D Nanomaterial Sensor for Selective and Sensitive Detection of H2S in Live Cells

• DOI: 10.1021/acsabm.0c00657
• Publication Date: 2020-08-10T04:04:06Z
• Authors: Mingming Wang; Yang Song; Peng Mu; Xiaoli Cai; Yuehe Lin; Chun-Long Chen
• Keywords: Peptoid; Nanomaterials; Biocompatible material

During the past few decades, a variety of two-dimensional (2D) nanomaterials have been developed through molecular self-assembly. Among them, those assembled from sequence-defined polymers received particular attention because they enable programmable display functional groups, including fluorescent dyes, on their surfaces for applications. On other hand, due to fluorescence self-quenching, synthesis 2D exhibiting high quantum yields is significant challenge. Herein, we design and synthesize peptoid-based crystalline nanomembranes (2DNMs) as biocompatible sensor selectively sensitively detecting H2S in live cells. This 2DNM peptoids covalently attached with H2S-responsive probes. Compared its amorphous controls, this exhibits significantly stronger intensity higher sensitivity result long-range structural ordering alignment By sonication-cutting these sensors into colloidal form an aqueous solution, further demonstrated use 2DNMs exogenous endogenous inside cells targeted cell organelles. Because are programmable, expect that class offer great potential investigating H2S-related diseases.