Multifunctional Hybrid Nanoprobe for Photoacoustic/PET/MR Imaging-Guided Photothermal Therapy of Laryngeal Cancer

• DOI: 10.1021/acsabm.1c00423
• Publication Date: 2021-06-03T21:45:16Z
• Authors: Jinghua Sun; Liping Li; Wenwen Cai; Anqi Chen; Ruiping Zhang
• Keywords: Nanoprobe

Laryngeal cancer is highly aggressive and insensitive to conventional targeted therapies, which often result in poor therapeutic outcomes. Image-guided precision therapy a promising strategy oncology that has superior safety efficacy versus therapies. Here, we present multifunctional theranostic nanoplatform based on melanin-coated gold nanorod (GNR) exhibits excellent multimodal imaging ability photothermal effects. These attributes make the platform applicable for photoacoustic (PA)/positron emission tomography (PET)/magnetic resonance (MR) image-guided treatment of laryngeal cancer. The melanin nanoparticles markedly suppress cytotoxicity template cetyltrimethylammonium bromide bilayer conferred GNR with PET/MR performances, due their native biocompatibilities strong affinities metal ions. Moreover, introduction greatly improved near-infrared absorbances passive targeting capabilities, leading exceptional PA ablation tumors. high stability dispersity under physiological conditions. After intravenous injection, could be precisely tracked vivo enabled laryngopharyngeal superficial located imaged. Combined effectively ablated tumors negligible side Thus, this work presents unique biocompatible allows imaging, anti-tumor PTT efficacy, effects