Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing

• DOI: 10.1021/acsami.0c00782
• Publication Date: 2020-06-01T13:48:44Z
• Authors: Shuai Liu; Xin Liu; Yanhan Ren; Penghui Wang; Yajie Pu; Rong Yang; Xiaoxue Wang; Xiaoyan Tan; Zhiwen Ye; Victor Maurizot; Bo Chi
• Keywords: Granulation tissue

Physicians have long been calling for an inherent antimicrobial wound dressing, which will be a great progress treating complicated infections. Here, we report novel bioadhesive hydrogel with antibacterial properties prepared by mixing modified hyaluronic acid (HA) and ε-polylysine (EPL). This can effectively kill Gram (+) (−) bacteria its high positive charge density on the surface. The sol–gel transition occurs within seconds via horseradish peroxidase enzymatic cross-linking Schiff base reaction, also allows to recover completely from destruction quickly 5 min. In infected rat model, histological studies indicated that hydrogels killed surface of wounds accelerated healing. Histological analysis thickness newborn skin, microvascular, granulation tissue, collagen rats treated dressings were twice as those commercial fibrin glue. These results indicate HA/EPL has potential dressing future clinical applications.