Universal Antibacterial Surfaces Fabricated from Quaternary Ammonium Salt-Based PNIPAM Microgels

• DOI: 10.1021/acsami.0c00791
• Publication Date: 2020-04-07T16:23:29Z
• Authors: Ziqing Zhao; Xiaoliang Ma; Rui Chen; Hui Xue; Jiehua Lei; Hui Du; Zexin Zhang; Hong Chen
• Keywords: Quaternary Ammonium Compounds; Drug Carriers; Microgels; Acrylic Resins; Escherichia coli; Microbial Sensitivity Tests; 01 natural sciences; 6. Clean water; Anti-Bacterial Agents; 0104 chemical sciences

Because of the excellent film-forming ability poly(N-isopropylacrylamide) (PNIPAM) microgel and high-efficient bactericidal property quaternary ammonium salt (QAS), QAS-based PNIPAM (QAS-PNIPAM) microgels are synthesized employed to modify surface a range commonly used materials including metal, plastic, elastomer. Bacterial culture is carried out on such QAS-PNIPAM microgel-modified surfaces examine viability attached bacteria. It found that efficiency nearly 100% modified all studied materials. We attribute performance film QAS component rather than topography itself. In addition, robust shows great integrity even after bacteria repeated rinses, cell experiment demonstrates this cyto-compatible. Therefore, simple, versatile method preparing antibacterial films paves way for future applications.