Europium–Pyridinedicarboxylate–Adenine Light-Up Fluorescence Nanoprobes for Selective Detection of Phosphate in Biological Fluids

• DOI: 10.1021/acsami.0c04318
• Publication Date: 2020-04-29T08:07:04Z
• Authors: Chen-Xi Zhao; Xiao-Ping Zhang; Yang Shu; Jian-Hua Wang
• Keywords: Europium

Phosphate (Pi) plays important roles in various physiological processes. Its quantification biological fluids is highly crucial for timely warning of Pi accumulation. Herein, an europium (Eu)-based coordination polymer nanoprobe (Eu/DPA/Ade) prepared by coordinating 2,6-pyridinedicarboxylic acid (2,6-DPA) and adenine (Ade) with Eu3+. Eu/DPA/Ade exhibits light-up fluorescence response to Pi. The strong interaction between Eu3+ O atoms the group not only shortens Eu3+-ligand distance improve energy transfer from 2,6-DPA but also attenuates quenching water molecules sphere produces red emission at λem 618 nm via "antenna effect". coligand Ade further promotes fluorescent emission. selective recognition within 10–60 μM achieved a detection limit 4.65 μM. In addition, certain level (100–170 μM) causes exponential increment on makes it feasible visual estimation under irradiation ultraviolet lamp 254 nm. quantitative human urine saliva have been demonstrated.