Remote Control of Neural Stem Cell Fate Using NIR-Responsive Photoswitching Upconversion Nanoparticle Constructs

• DOI: 10.1021/acsami.0c10145
• Publication Date: 2020-08-11T18:44:06Z
• Authors: Yixiao Zhang; Lisa M. Wiesholler; Hudifah Rabie; Pengfei Jiang; Jinping Lai; Thomas Hirsch; Ki-Bum Lee
• Keywords: Photon Upconversion; Regenerative Medicine; Phototoxicity

Light-mediated remote control of stem cell fate, such as proliferation, differentiation, and migration, can bring a significant impact on biology regenerative medicine. Current UV/vis-mediated approaches are limited in terms nonspecific absorption, poor tissue penetration, phototoxicity. Upconversion nanoparticle (UCNP)-based near-infrared (NIR)-mediated systems have gained increasing attention for vast applications with minimal good penetration depth, phototoxicity from NIR excitations. Specifically, 808 nm NIR-responsive upconversion nanomaterials shown clear advantages biomedical owing to diminished heating effects better penetration. Herein, novel NIR-mediated method differentiation has been developed using multishell UCNPs, which optimized upconverting light UV emission. The locally generated emissions further toggle photoswitching polymer capping ligands achieve spatiotemporally controlled small-molecule release. More specifically, excitation, factors be released guide neural (NSC) highly manner. Given the challenges behavior control, UCNP-based approach represent new tool studying single-molecule roles developmental biology.