Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma

• DOI: 10.1021/acsami.0c12971
• Publication Date: 2020-11-09T19:45:41Z
• Authors: Haoyue Xu; Yuhan Han; Gang Zhao; Long Zhang; Zongren Zhao; Zhen Wang; Liang Zhao; Lei Hua; Konduru Naveena; Jun Lu; Rutong Yu; Hongmei Liu
• Keywords: Indocyanine Green; Hypoxia; Tumor Hypoxia

Glioma is the most prevalent type of malignant brain tumor and usually very aggressive. Because high invasiveness aggressive proliferative growth glioma, it difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause postoperative recurrence. Herein, we describe hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), photothermal (PTT) combination multitherapy strategies targeting glioma. The LN [LN (DOX + ICG)] contains component poly(nitroimidazole)25 [P-(Nis)25], glioma-targeting peptide angiopep-2 (A2), indocyanine green (ICG), doxorubicin (DOX). ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) hydrophobic hypoxia responsive ability encapsulate DOX ICG; (ii) allows rapid release from after 808 nm laser irradiation; (3) ICG: ICG imaging-guided combining PDT PTT therapies; upon irradiation an laser, creates hypoxic environment; (4) inhibits growth. This work demonstrates that might provide novel clinical approach preventing post-surgical recurrence