Protein Adsorption on Surfaces Functionalized with COOH Groups Promotes Anti-inflammatory Macrophage Responses

• DOI: 10.1021/acsami.0c16509
• Publication Date: 2021-02-06T15:33:37Z
• Authors: Emily Buck; Seunghwan Lee; Laura S. Stone; Marta Cerruti
• Keywords: Protein Adsorption; Foreign-body giant cell; Biomaterial

Implants can induce a foreign body reaction that leads to chronic inflammation and fibrosis in the surrounding tissue. Macrophages help detect material, play role inflammatory response, may promote instead of desired tissue regeneration around implants. Implant surface properties impact macrophage responses by changing nature adsorbed protein layer, but conflicting studies highlight complexity this relationship. In study, effect chemistry on behavior was investigated with poly(styrene) surfaces containing common functional groups at similar densities. The layer characterized identify proteins from medium secreted onto adherent macrophages. Of chemistries studied, carboxylic acid (COOH) promoted anti-inflammatory unstimulated macrophages did not exacerbate upon stimulation. These also enhanced adsorption involved integrin signaling secretion related angiogenesis, signaling, cytokine which have been previously associated improved biomaterial integration. Therefore, study suggests modification COOH improve integration implants enhancing through altered adsorption.