Functional Transdermal Nanoethosomes Enhance Photodynamic Therapy of Hypertrophic Scars via Self-Generating Oxygen

• DOI: 10.1021/acsami.0c20667
• Publication Date: 2021-02-10T18:28:01Z
• Authors: Yunsheng Chen; Zheng Zhang; Yu Xin; Zhixi Yu; Xinxian Meng; Ying Zhang; Dannong He; Yixin Zhang
• Keywords: Dermal fibroblast

Photodynamic therapy (PDT) is a new therapeutic strategy for hypertrophic scars (HSs), and nanoethosomes (ES) have attracted considerable attention as an efficient transdermal delivery system PDT of HSs (HS-PDT). However, the photosensitizers hypoxic microenvironment limit HS-PDT efficacy. Consequently, functional ES (A/A-ES) that are loaded with photosensitizer, 5-aminolevulinic acid (ALA), immobilized nanoenzyme Au nanoclusters (ANCs) within surface been developed exhibit superior co-delivery characteristics produce catalase enhances The unique structure A/A-ES enables them to co-deliver ALA ANCs into HS tissue efficiently decompose endogenous hydrogen peroxide in generate oxygen. findings from vitro vivo experiments demonstrated co-delivered they improved HS. Systematic assessments reveal enhance efficacy highly effective at improving morphology promoting fibroblast apoptosis rearrangement collagen. These works give rise treatment option integrates nanoenzymes, thereby enabling exert their respective beneficial effects, highlight enhancement via self-generating