Regulation of Blood Glucose Using Islets Encapsulated in a Melanin-Modified Immune-Shielding Hydrogel

• DOI: 10.1021/acsami.0c23010
• Publication Date: 2021-03-10T19:31:50Z
• Authors: Ling Huang; Jiajia Xiang; Yukai Cheng; Ling Xiao; Qingqing Wang; Yini Zhang; Tieling Xu; Qianrui Chen; Hongbo Xin; Xiaolei Wang
• Keywords: Blood sugar regulation

Islet transplantation is currently a promising treatment for type 1 diabetes mellitus. However, the foreign body reaction and retrieval difficulty often lead to failure hinder clinical application. To address these two challenges, we propose balanced charged sodium alginate–polyethyleneimine–melanin (SA–PEI–Melanin) threadlike hydrogel with immune shielding retrievable properties. The attractiveness of this study lies in that introduction melanin can stimulate insulin secretion, especially under near-infrared (NIR) irradiation. After demonstrating good immune-shielding effect, performed an vivo experiment. results showed blood glucose level SA–PEI–Melanin group was stably controlled below diabetic criterion, could be further adjusted after NIR In addition, evaluation retrieving indicated islets still maintained normal physiological function, proving its excellent immunological protection. This provides new approach accurate regulation patients mellitus contributes developing transplant system reconcile real-time precise light-defined secretion regulation.