Synergistic Chemo-thermal Therapy of Cancer by DNA-Templated Silver Nanoclusters and Polydopamine Nanoparticles

• DOI: 10.1021/acsami.1c04608
• Publication Date: 2021-04-28T01:42:34Z
• Authors: Yiting Jiang; Minxuan Sun; Nan Ouyang; Yuguo Tang; Peng Miao
• Keywords: Nanoclusters; Absorbance

Herein, we develop a novel and effective combination nanoplatform for cancer theranostics. Folic acid (FA) is first modified on the photothermal agent of polydopamine (PDA), which possesses excellent near-infrared (NIR) absorbance thermal conversion features. Temperature-sensitive silver nanoclusters (AgNCs) are then synthesized DNA template that also loads anticancer drug doxorubicin (Dox). After accumulation in cells, PDA generates cytotoxic heat upon excitation NIR light therapy. On other hand, temperature increment able to destroy AgNCs, leading fluorescence variation controlled release Dox chemotherapy. The combined nanosystem exhibits outstanding tracing, transduction, as well chemo delivery capabilities. Both vitro vivo results demonstrate tumor growth suppression phenomena no apparent adverse effects. This research provides powerful targeted theranostics, may have great potential value future clinical applications.