Immunochromatographic Assay Based on Polydopamine-Decorated Iridium Oxide Nanoparticles for the Rapid Detection of Salbutamol in Food Samples

• DOI: 10.1021/acsami.1c06724
• Publication Date: 2021-06-09T20:03:20Z
• Authors: Shuang Zhao; Tong Bu; Kairong Yang; Zhihao Xu; Feier Bai; Kunyi He; Lihua Li; Li Wang
• Keywords: Biocompatibility

Salbutamol (SAL), a β-2 adrenoreceptor agonist, is an unpopular addition to livestock and poultry, causing several side effects human health. Thus, it very important develop simple rapid analytical method screen SAL in the field of food safety. Here, we present immunochromatographic assay (ICA) for sensitively detecting with polydopamine-decorated iridium oxide nanoparticles (IrO2@PDA NPs) as signal tag. The IrO2@PDA excellent hydrophilicity, biocompatibility, stability was synthesized by oxidating self-polymerization dopamine hydrochloride (DAH) on surface IrO2 NPs used label monoclonal antibodies (mAbs) through physical adsorption. Compared NPs, also possessed superior optical properties higher affinity mAbs. With proposed method, limit detection 0.002 ng/mL, which improved at least 24-fold 180-fold compared NPs-based ICA conventional gold nanoparticles-based ICA, respectively. Furthermore, residuals pork, pork liver, beef were successfully detected developed biosensor recoveries ranged from 85.56% 115.56%. Briefly, this work indicated that powerful IrO2@PDA-based can significantly improve sensitivity has huge potential accurate sensitive harmful small molecules analytes safety fields.