TiO2 Nanotubes Alginate Hydrogel Scaffold for Rapid Sensing of Sweat Biomarkers: Lactate and Glucose

• DOI: 10.1021/acsami.1c11446
• Publication Date: 2021-08-03T01:55:40Z
• Authors: Udara Bimendra Gu...; Sandra Garcia-Rey; Edilberto Ojeda; Lourdes Basabe-De...; Fernando Benito-L...
• Keywords: Titanium Dioxide; Biocompatibility; Glucose oxidase

Versatile sensing matrixes are essential for the development of enzyme-immobilized optical biosensors. A novel three-dimensional titanium dioxide nanotubes/alginate hydrogel scaffold is proposed detection sweat biomarkers, lactate, and glucose in artificial sweat. Hydrothermally synthesized nanotubes were introduced to alginate polymeric matrix, followed by cross-linking nanocomposite with dicationic calcium ions fabricate platform. Rapid colorimetric (blue color signal) was carried out both lactate biomarkers at 4 6 min, respectively. The superhydrophilicity capillarity nanotubes, when incorporated into facilitate rapid transfer components throughout sensor scaffold, decreasing times. Moreover, integrated on a cellulose paper demonstrate adaptability material other matrixes, obtaining fast homogeneous substrate image analysis performed. properties this new composite provide avenues paper-based devices. biocompatibility, efficient immobilization biological enzymes/colorimetric assays, quick signal readout behavior scaffolds prospective opportunity integration wearable