Selenium Vacancy Engineering Using Bi2Se3 Nanodots for Boosting Highly Efficient Photonic Hyperthermia
Mice, Inbred BALB C
Infrared Rays
Photothermal Therapy
Contrast Media
Antineoplastic Agents
Serum Albumin, Bovine
02 engineering and technology
01 natural sciences
0104 chemical sciences
Photoacoustic Techniques
Folic Acid
Models, Chemical
Cell Line, Tumor
Neoplasms
0103 physical sciences
Quantum Dots
Animals
Cattle
Female
Selenium Compounds
0210 nano-technology
Bismuth
Density Functional Theory
DOI:
10.1021/acsami.1c13107
Publication Date:
2021-10-11T06:40:21Z
AUTHORS (8)
ABSTRACT
Despite bismuth-based energy conversion nanomaterials having attracted extensive attention for nanomedicine, the nanomaterials suffer from major shortcomings including low tumor accumulation, long internal retention time, and undesirable photothermal conversion efficiency (PCE). To combat these challenges, bovine serum albumin and folic acid co-modified Bi2Se3 nanomedicine with rich selenium vacancies (abbreviated as VSe-BS) was fabricated for the second near-infrared (NIR-II) light-triggered photonic hyperthermia. More importantly, selenium vacancies on the crystal planes (0 1 5) and (0 1 11) of VSe-BS with similar formation energies could be distinctively observed via aberration-corrected scanning transmission electron microscopy images. The defect engineering endows VSe-BS with enhanced conductivity, making VSe-BS possess outstanding PCE (54.1%) in the NIR-II biowindow and desirable photoacoustic imaging performance. Tumor ablation studies indicate that VSe-BS possesses satisfactory therapeutic outcomes triggered by NIR-II light. These findings give rise to inspiration for further broadening the biological applications of defect engineering bismuth-based nanomaterials.
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