Injectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation

• DOI: 10.1021/acsami.1c13972
• Publication Date: 2021-10-15T14:59:22Z
• Authors: Mari C. Mañas-Torres; Cristina Gila-Vil...; Francisco J. Vazq...; Pavel Kuzhir; David Momier; Jean-Claude Scimeca; Arnaud Borderie; Marianne Goracci; Fanny Burel-Vande...; Cristina Blanco-E...; Ismael A. Rodriguez; Miguel Alaminos; Luis Álvarez de C...; Modesto T. Lopez-...
• Keywords: Biocompatibility; Biocompatible material

The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce hydrogels has broadened the scope these materials biomedical research. Embedded MNP offer possibility modulate physical properties remotely and on demand by applying an external field. Moreover, they enable permanent changes mechanical hydrogel, as well alterations micro- macroporosity its three-dimensional (3D) structure, with associated potential induce anisotropy. In this work, behavior biocompatible biodegradable made Fmoc-diphenylalanine (Fmoc-FF) (Fmoc = fluorenylmethoxycarbonyl) Fmoc-arginine-glycine-aspartic acid (Fmoc-RGD) short peptides which were incorporated was studied detail physicochemical, mechanical, biological methods. resulting hybrid showed enhance withstood injection without phase disruption. mice, faster improved self-healing compared their nonmagnetic counterparts. Thanks superior stability during culture, can be used 3D scaffolds for cell growth. Additionally, short-peptide good biocompatibility absence toxicity, together enhanced excellent injectability make them ideal biomaterials vivo applications minimally invasive surgery. This study presents new approach improving supramolecular incorporating MNP, confer structural reinforcement stability, remote actuation fields, better injectability. Our is catalyst expanding hydrogels.