Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA

• DOI: 10.1021/acsami.1c15494
• Publication Date: 2021-10-11T19:00:08Z
• Authors: Bo Yang; Zhihan Zhao; Yufan Pan; Jiayin Xie; Bini Zhou; Yujie Li; Yuanchen Dong; Dongsheng Liu
• Keywords: Linker; Biocompatibility

A novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the formation, self-dimer with two sticky ends as linker to induce gelation of B-Y. By programing sequence, thermal and metal-ion responsiveness could be introduced into this system. This shows shear-thinning, designable responsiveness, good biocompatibility, which will simplify composition preparation process accelerate its biomedical applications.