Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing

• DOI: 10.1021/acsami.1c19209
• Publication Date: 2022-01-05T15:53:32Z
• Authors: Wei-Nan Zeng; Duan Wang; Qiu-Ping Yu; Ze-Ping Yu; Hao-Yang Wang; Cheng-Yu Wu; Si-Wei Du; Xing-Yu Chen; Jia-Fei Li; Zong-Ke Zhou; Yu Zeng; Yun Zhang
• Keywords: Biocompatibility; Photothermal effect

The successful treatment of infected wounds requires strategies with effective antimicrobial, anti-inflammatory, and healing-promoting properties. Accordingly, the use Cu2+ tetracycline (TC), which can promote angiogenesis, re-epithelialization, collagen deposition, also antibacterial activity, at wound site, has shown application prospects in promoting repair. However, realizing controllable release to prolong action time avoid potential toxicities is critical. Moreover, near-infrared light (NIR)-activated mesoporous polydopamine nanoparticles (MPDA NPs) reportedly exert anti-inflammatory effects by eliminating reactive oxygen species generated during inflammatory responses. In this study, we assess whether TC loaded MPDA NPs accelerate healing mice. particular, chelated immobilized on surface NPs, while a thermosensitive phase-change material (PCM; melting point: 39-40 °C), combined antibiotics, was into as gatekeeper (PPMD@Cu/TC). Results show that PPMD@Cu/TC exhibits significant great photothermal properties NIR irradiation, induces Cu2+, inducing PCM and, subsequent, release. combination therapy, NIR-triggered enables nanocomposite eradicate bacterial infections healing. Importantly, negligible damage primary organs satisfactory biocompatibility were observed murine model. Collectively, these findings highlight therapeutic MPDA-based platform for controlling infection accelerating