Metal Phenolic Nanodressing of Porous Polymer Scaffolds for Enhanced Bone Regeneration via Interfacial Gating Growth Factor Release and Stem Cell Differentiation

• DOI: 10.1021/acsami.1c19633
• Publication Date: 2021-12-28T08:36:19Z
• Authors: Yaping Zhang; Kai Li; Lanbo Shen; Lu Yu; Tian Ding; Baojin Ma; Shaohua Ge; Jianhua Li
• Keywords: Bioactive Glass; Bone tissue

Porous polymer scaffolds are essential materials for tissue engineering because they can be easily processed to deliver stem cells or bioactive factors. However, made of synthetic polymers normally lack a cell-material interface and undergo burst release growth factors, which may hinder their further application in engineering. In this paper, metal-phenolic network (MPN) was interfacially constructed on the pore surface porous poly(dl-lactide) (PPLA) scaffold. Based molecular gating property MPN supramolecular structure, PPLA@MPN scaffold achieved sustained loaded molecules. addition, coating provided interface, thus encouraging migration osteogenic differentiation bone marrow mesenchymal (BMSCs). The exhibited enhanced regeneration rat femoral defect model vivo compared PPLA, is ascribed combined effect morphogenetic protein-2 (BMP-2) ability MPN. This nanodressing technique provides viable straightforward strategy enhancing performance