Achieving Adjustable Multifunction Based on Host–Guest Interaction-Manipulated Reversible Molecular Conformational Switching

• DOI: 10.1021/acsami.1c22172
• Publication Date: 2021-12-27T09:13:35Z
• Authors: Dong Li; Yujie Han; Yanrong Jiang; Guanyu Jiang; Haitao Sun; Zhenrong Sun; Qi-Wei Zhang; Yang Tian
• Keywords: Molecular switch; Conformational change; Molecular conformation

Small molecules that are capable of toggling between multiple and definite conformational states under external stimuli have great potential for use in molecular switches or sensors. However, currently developed regulation approaches these switchable mostly involve covalent bond-breaking/reforming processes, thereby inevitably producing byproducts causing fatigue accumulation. Herein, we report a simple but successful model whose conformation can be precisely manipulated stretched folded forms by employing host-guest interactions with rigid macrocycles, thus avoiding possible side reactions accumulation possessing excellent reversibility. Moreover, the this molecule visualized identified luminous readout, endowing it real-time self-reporting features. Furthermore, controllable reversible conversion is accompanied various valuable functions, including multicolor emission; ratiometric fluorescent thermosensing high temperature resolution, reversibility, lock/unlock switching, especially linear detection range tunability; addition intracellular sensing imaging, disclosing intriguing microscopic "conformation-function" relationship based on single molecule.