Anchoring Group-Mediated Radiolabeling of Inorganic Nanoparticles─A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes

• DOI: 10.1021/acsami.1c23907
• Publication Date: 2022-02-08T17:07:53Z
• Authors: Jianxian Ge; Lei Chen; Baoxing Huang; Yun Gao; Dandan Zhou; Yi Zhou; Can Chen; Ling Wen; Qing Li; Jianfeng Zeng; Zhiyuan Zhong; Mingyuan Gao
• Keywords: Nuclide; Biocompatibility; Nuclear imaging

Nuclear medicine imaging has aroused great interest in the design and synthesis of versatile radioactive nanoprobes, while most methods developed for radiolabeling nanoprobes are difficult to satisfy criteria clinical translation, including easy operation, mild labeling conditions, high efficiency, stability. Herein, we demonstrated universality a simple but efficient method recently constructing nuclear that is, ligand anchoring group-mediated (LAGMERAL). In this method, diphosphonate-polyethylene glycol (DP-PEG) decorating on surface inorganic nanoparticles plays an essential role. principle, owing strong binding affinity variety metal ions, it can not only endow underlying containing ions some main group transition lanthanide with excellent colloidal stability biocompatibility also enable through diphosphonate group. Based assumption, such as Fe3O4 nanoparticles, NaGdF4:Yb,Tm Cu2-xS representatives functional suitable different modalities magnetic resonance (MRI), upconversion luminescence (UCL), photoacoustic (PAI), respectively, were chosen be radiolabeled kinds radionuclides SPECT nuclides (e.g., 99mTc), PET 68Ga), therapeutic 177Lu) demonstrate reliability LAGMERAL approach. The experimental results showed obtained exhibited stability, whole process had negligible impacts physical chemical properties initial nanoparticles. Through passive targeting SPECT/MRI glioma tumor, active SPECT/UCL colorectal cancer, SPECT/PAI lymphatic metastasis, outstanding potentials resulting sensitive tumor diagnosis demonstrated, manifesting feasibility efficiency LAGMERAL.