Tannic Acid–Iron Complex-Based Nanoparticles as a Novel Tool against Oxidative Stress

• DOI: 10.1021/acsami.1c24576
• Publication Date: 2022-03-30T14:21:58Z
• Authors: Carlotta Pucci; Chiara Martinelli; Daniele De Pasquale; Matteo Battaglini; Nicoletta di Leo; Andrea Degl’Innoc...; Melike Belenli Gümüş; Filippo Drago; Gianni Ciofani
• Keywords: Tannic acid

Accumulation of reactive oxygen species in cells leads to oxidative stress, with consequent damage for cellular components and activation cell-death mechanisms. Oxidative stress is often associated age-related conditions, as well several neurodegenerative diseases. For this reason, antioxidant molecules have attracted a lot attention, especially those derived from natural sources─like polyphenols tannins. The main issue related the use antioxidants their inherent tendency be oxidized, quick enzymatic degradation biological fluids, poor bioavailability. Nanomedicine, sense, has helped finding new solutions deliver protect antioxidants; however, concentration encapsulated molecule conventional nanosystems could very low and, therefore, less effective. We propose exploit properties tannic acid, known plant-derived antioxidant, chelate iron ions, forming hydrophobic complexes that can coated biocompatible biodegradable phospholipid improve stability media. By combining nanoprecipitation hot sonication procedures, we obtained three-dimensional networks composed acid-iron hydrodynamic diameter ≈200 nm. These nanostructures show scavenging activity after induction an acute chemical pro-oxidant insult; moreover, they also demonstrated counteract induced by both vitro on vivo model organism (planarians).