pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

• DOI: 10.1021/acsami.2c00580
• Publication Date: 2022-04-08T15:48:48Z
• Authors: Huimin Chen; Jing Cheng; Xixi Cai; Jinzhi Han; Xu Chen; Lijun You; Caihua Xiong; Shaoyun Wang
• Keywords: 0301 basic medicine; Wound Healing; 03 medical and health sciences; Anti-Infective Agents; Biofilms; Wound Infection; Humans; Hydrogels; 02 engineering and technology; Hydrogen-Ion Concentration; 0210 nano-technology; Anti-Bacterial Agents

Biofilm infection will cause chronic inflammation and hinder the normal healing process of wound. Here, based on self-assembly three designed amphiphilic pentapeptides named EK, GG, DR, pH-switchable antibacterial hydrogels with fiber network are used for eradication biofilms rescue delayed in infected wounds. These pentapeptides-based exhibit an acidic antimicrobial effect biocompatible at neutral pH. Additionally, supramolecular nanofiber networks physical cross-linking thermosensitive polymers (PNIPAm) loaded oregano oil further developed. In vitro experiments indicate that activity comes from disassembly pH-dependent activated release oil, which achieves synergistic biofilm eradication. Remarkably, DR-based hydrogel improves efficiency full-thickness wound skin vivo, is manifested by increased closure rate, reduced inflammatory response, faster angiogenesis, collagen deposition wound, exhibiting great potential as dressing. The proposed strategy inhibiting formation activating may provide efficient method treatment clinically