pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing
0301 basic medicine
Wound Healing
03 medical and health sciences
Anti-Infective Agents
Biofilms
Wound Infection
Humans
Hydrogels
02 engineering and technology
Hydrogen-Ion Concentration
0210 nano-technology
Anti-Bacterial Agents
DOI:
10.1021/acsami.2c00580
Publication Date:
2022-04-08T15:48:48Z
AUTHORS (8)
ABSTRACT
Biofilm infection will cause chronic inflammation and hinder the normal healing process of wound. Here, based on self-assembly three designed amphiphilic pentapeptides named EK, GG, DR, pH-switchable antibacterial hydrogels with fiber network are used for eradication biofilms rescue delayed in infected wounds. These pentapeptides-based exhibit an acidic antimicrobial effect biocompatible at neutral pH. Additionally, supramolecular nanofiber networks physical cross-linking thermosensitive polymers (PNIPAm) loaded oregano oil further developed. In vitro experiments indicate that activity comes from disassembly pH-dependent activated release oil, which achieves synergistic biofilm eradication. Remarkably, DR-based hydrogel improves efficiency full-thickness wound skin vivo, is manifested by increased closure rate, reduced inflammatory response, faster angiogenesis, collagen deposition wound, exhibiting great potential as dressing. The proposed strategy inhibiting formation activating may provide efficient method treatment clinically
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