Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A “Pull–Push” Approach

• DOI: 10.1021/acsami.2c04300
• Publication Date: 2022-06-01T20:23:36Z
• Authors: Kunbao Zhang; Chao Yang; Chuanxu Cheng; Chengxin Shi; Madi Sun; Hanze Hu; Tongfei Shi; Xuenian Chen; Xuan He; Xiao Zheng; Mingqiang Li; Dan Shao
• Keywords: Push pull; Wound dressing

Chronic diabetic wound healing remains a challenge due to the existence of excessive danger molecules and bacteria in inflammatory microenvironment. There is an urgent need for advanced dressings that target both inflammation infection. Here, bioactive hydrogel without loading any anti-inflammatory ingredients rationally designed achieve "Pull–Push" approach efficient safe bacteria-infected by integrating molecule scavenging (Pull) with antibiotic delivery (Push) The cationic hydrogel, termed OCMC-Tob/PEI fabricated conjugation polyethylenimine (PEI) tobramycin (Tob) on oxidized carboxymethyl cellulose (OCMC) backbone via Schiff base reaction injectable, self-healing, biocompatible properties. not only displays remarkable capability capturing multiple negatively charged (e.g., cell-free DNA, lipopolysaccharides, tumor necrosis factor-α) ameliorate anti-inflammation effects but also achieves controllable long-term antibacterial activity pH-sensitive release Tob. Consequently, this multifunctional greatly expedites closure rate combined anti-infection Pseudomonas aeruginosa-infected wounds. Our work provides highly versatile treatment chronic wounds promising dressing regenerative medicine.