Piezoelectric Activatable Nanozyme-Based Skin Patch for Rapid Wound Disinfection

• DOI: 10.1021/acsami.2c05114
• Publication Date: 2022-06-01T13:12:06Z
• Authors: Qiang Bai; Jiancheng Zhang; Yixin Yu; Chaohui Zhang; Yujie Jiang; Dongqin Yang; Manhong Liu; Lina Wang; Fanglin Du; Ning Sui; Zhiling Zhu
• Keywords: 02 engineering and technology; 0210 nano-technology

Nanozymes are promising new-generation antibacterial agents owing to their low cost, high stability, broad-spectrum activity, and minimal antimicrobial resistance. However, the inherent catalytic activity of nanozymes tends limit efficacy. Herein, a heterostructure zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR) with unparallel piezocatalytic enzyme mimic is reported, which concurrently possesses intrinsic peroxidase-like strong piezoelectric responses effectively promotes decomposition hydrogen peroxide (H2O2) generation reactive oxygen species under ultrasound irradiation. Moreover, this nanozyme exhibits almost 100% efficacy against multidrug-resistant pathogens involving methicillin-resistant Staphylococcus aureus Pseudomonas aeruginosa in vitro vivo. In addition, activatable nanozyme-based skin patch developed for rapid wound disinfections satisfactory hemocompatibility cytocompatibility. This work not only sheds light on development an innovative disinfection but also provides new insights engineering therapy.