Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products

• DOI: 10.1021/acsami.2c06841
• Publication Date: 2022-08-22T17:09:41Z
• Authors: Tina Skorjanc; Dinesh Shetty; Felipe Gándara; Simon Pascal; Nawavi Naleem; Salma Abubakar; Liaqat Ali; Abdul Khayum Moha...; Jesus Raya; Serdal Kirmizialtin; Olivier Siri; Ali Trabolsi
• Keywords: Cationic polymerization; Surface Modification; Covalent organic framework

Azacalix[n]arenes (ACAs) are lesser-known cousins of calix[n]arenes that contain amine bridges instead methylene bridges, so they generally have higher flexibility due to enlarged cavities. Herein, we report a highly substituted cationic azacalix[4]arene-based covalent organic framework (ACA-COF) synthesized by the Zincke reaction under microwave irradiation. The current work is rare example synthetic strategy utilizes chemical functionalization an macrocycle constrain its conformational and, thereby, produce ordered material. Considering ACA cavity dimensions, and density diversity polar groups in ACA-COF, used it for adsorption uric acid creatinine, two major waste products generated during hemodialysis treatment patients with renal failure. This type application, which has potential save ∼400 L water per patient week, only been recognized last decade, but could effectively address problem scarcity arid areas world. Rapid rates (up k = 2191 g mg-1 min-1) were observed our COF, exceeding reported values several orders magnitude.