Aperture Modulation of Isoreticular Metal Organic Frameworks for Targeted Antitumor Drug Delivery

• DOI: 10.1021/acsami.2c07450
• Publication Date: 2022-07-28T03:51:11Z
• Authors: Mengru Cai; Wulin Liang; Kaixin Wang; Dongge Yin; Tingting Fu; Rongyue Zhu; Changhai Qu; Xiaoxv Dong; Jian Ni; Xingbin Yin
• Keywords: Targeted drug delivery

The introduction of different pore diameters in metal organic frameworks (MOFs) could adjust their drug delivery performance. MOFs with customized structures have potential application value targeted delivery. However, no research on this topic has been found so far. In report, isoreticular (IRMOFs) taken as a typical case tailor-made MOFs, the size which is enlarged (average BJH sizes about 2.43, 3.06, 5.47, and 6.50 nm were determined for IRMOF-1, IRMOF-8, IRMOF-10, IRMOF-16, respectively), emphasizing relationship between model drugs (Oridonin, ORI) clarifying its working mechanism. whose matches ORI, an outstanding loading capacity (57.93% by wt) release profile (about 90% 24 h at pH 7.4). IRMOF-1 was further coated polyethylene glycol (PEG) modified cell penetrating peptide (CPP44) bound to M160 (CD163L1) protein targeting hepatic tumor lines. This nanoplatform (CPP44-PEG@ORI@IRMOF-1) exhibited acid-responsive behavior (37.86% 10 7.4 66.66% 5.5) significantly enhanced antitumor effects. results vivo animal imaging indicated that CPP44-PEG@ORI@IRMOF-1 may serve tumor-selective nanoplatform. Toxicity assessment confirmed PEGylated did not cause organ or systemic toxicity. Furthermore, it encouraging IRMOF-based system modulation showed rapid clearance (most administered NPs are metabolized from urine feces within 1 week) avoided accumulation body, indicating promise biomedical applications. MOF-based aperture combined modification strategy might find broad applications cancer theranostics. Thus, convenient customize personalized according molecules future research.