Neutrophil-Biomimetic “Nanobuffer” for Remodeling the Microenvironment in the Infarct Core and Protecting Neurons in the Penumbra via Neutralization of Detrimental Factors to Treat Ischemic Stroke

• DOI: 10.1021/acsami.2c09020
• Publication Date: 2022-06-13T06:49:02Z
• Authors: Shanshan Liu; Jianpei Xu; Yipu Liu; Yang You; Laozhi Xie; Shiqiang Tong; Yu Chen; Kaifan Liang; Songlei Zhou; Fengan Li; Zhuang Tang; Ni Mei; Huiping Lu; Xiaolin Wang; Xiaoling Gao; Jun Chen
• Keywords: Penumbra

High level of detrimental factors including reactive oxygen species (ROS) and inflammatory cytokines accumulated in the infarct core their erosion to salvageable penumbra are key pathological cascades ischemia-reperfusion injury stroke. Few neuroprotectants can remodel hostile microenvironment for failure interfere with dead or biofunctionally inactive dying cells. Even is temporarily attenuated by medications; insults from still erode continuously along drug metabolism clearance. Herein, a strategy named "nanobuffer" proposed neutralize buffer destructive penumbra. Inspired neutrophils' tropism affinity cytokines, poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated neutrophil membrane target absorb cytokines; α-lipoic acid decorated on surface cannabidiol loaded ROS scavenging neuroprotection, respectively, construct basic unit nanobuffer. Such nanobuffer exerts comprehensive effect area via factor neutralization cannabidiol-induced neuroprotection. Besides, possibly be enhanced dynamic ROP (ring-opening-polymerization)-induced cross-fusion among closely adjacent units vivo. Systematic evaluations show significant decrease penumbra, reduced volume, improved neurological recovery compared untreated group stroke rats.