Periosteum-Inspired Membranes Integrated with Bioactive Magnesium Oxychloride Ceramic Nanoneedles for Guided Bone Regeneration

• DOI: 10.1021/acsami.2c10615
• Publication Date: 2022-08-26T18:57:13Z
• Authors: Yuwei Zhu; Bingyang Dai; Xu Li; Wei Liu; Jiangpeng Wang; Jiankun Xu; Shunxiang Xu; Xuan He; Shian Zhang; Quan Li; Ling Qin; To Ngai
• Keywords: 0301 basic medicine; Ceramics; 03 medical and health sciences; Bone Regeneration; Osteogenesis; Periosteum; Animals; Magnesium; Rats

Guided bone regeneration (GBR) technique using a barrier membrane holds great potential to allow the single-stage reconstruction of critical-sized bone defects. Here, bioactive nanoneedle-like magnesium oxychloride ceramics (MOCs) are synthesized and recruited as an osteoinductive factor within a polycaprolactone-gelatin A (PCL-GelA) membranous matrix to generate a periosteum-mimicking biphasic GBR membrane (PCL-GelA/MOC) to accelerate calvarial defect repair. The PCL-GelA/MOC membrane acts as a shield for defect areas and a reservoir of osteoinductive molecules, which provides a favorable microenvironment for supporting cell proliferation, infiltration, and differentiation. This membrane leads to accelerated osteogenesis and angiogenesis, effectual defect bridging, and significantly enhanced bone regeneration when applied to a 5 mm sized rat calvarial defect. This makes this innovative and multifunctional GBR membrane a suitable candidate for clinical applications with promising curative efficacy.