Porous Silicon Carrier Endowed with Photothermal and Therapeutic Effects for Synergistic Wound Disinfection

• DOI: 10.1021/acsami.2c12012
• Publication Date: 2022-10-24T07:46:33Z
• Authors: Wei Duan; Xingyue Liu; Jingwen Zhao; Yongke Zheng; Jianmin Wu
• Keywords: Surface Modification; Porous Silicon; Photothermal effect

Drug carriers endowed with photothermal effects will allow the drug delivery system to release drugs in a thermal-stimuli manner. In addition, therapy (PTT) also interplay therapeutic loaded carrier exhibit synergistic bioactivity for various disease treatment. However, endowing and still has challenge. Herein, we demonstrate that surface modification of porous silicon (PSi) polydopamine (PDA) could endow classical significant effect advanced antibacterial wound disinfection. Specifically, PSi interacts Cu2+/PDA complex via simple fast reduction-induced deposition method, forming unique CuPDA coated microcarrier (CuPPSi) without blocking mesoporous structure. The CuPPSi generates higher near-infrared (NIR) efficiency improved loading capacity owing abundant functional groups PDA. Stimuli-responsive Cu2+ curcumin (Cur) from can be realized under multiple stimuli including pH, reactive oxygen species NIR laser irradition. Benefited carrier's intrinsic multimodal therapy, CuPPSi-Cur platform exhibits amplified, broad-spectrum, effect, killing more than 98% both Staphylococcus aureus Escherichia coli at mild PTT temperature (∼45 °C). Notably, combined promotes migration fibroblasts no cytotoxicity as revealed through cell experiments vitro. bacteria-infected mice model, efficient bacterial ablation healing are further demonstrated negligible side vivo. Overall, rational design provides novel intervention amplifing disinfection clinically.