Sustainable and Chemoselective Synthesis of α-Aminonitriles Using Lewis and Brønsted Acid-Functionalized Nanoconfined Spaces

• DOI: 10.1021/acsami.2c13945
• Publication Date: 2022-10-27T08:50:24Z
• Authors: Chloe A. Ramsperger; Noah Q. Tufts; Ankit K. Yadav; Jacob M. Lessard; Kyriakos C. Styli...
• Keywords: Chemoselectivity; Brønsted–Lowry acid–base theory; Organic Synthesis; Lewis acid catalysis

α-Aminonitriles are significant components in the synthesis of biological compounds and complex drugs. Although efficient, procedures for synthesizing α-aminonitriles suffer from high loadings expensive catalysts, long reaction times, energy-intensive conditions, expensive, toxic solvents. Herein, we report use metal–organic framework Cr-MIL-101-SO3H as a catalyst facile eight α-aminonitriles, five which reported new molecules. We found that presence both open Cr3+ Lewis −SO3H Brønsted acids MIL-101 pores is vital one-pot α-aminonitriles. The catalytic conducted under solvent-free conditions at room temperature loading 1% by total mass, considered sustainable synthetic pathway Additionally, demonstrated first time exhibits degree chemoselectivity, differing substrates with sterically hindered electronically withdrawn functional groups. Our study expands existing family provides an intelligent strategy development catalysts can be used to synthesize potential therapeutics health applications.