In Situ Biomimetic Mineralization of Bone-Like Hydroxyapatite in Hydrogel for the Acceleration of Bone Regeneration

• DOI: 10.1021/acsami.2c16217
• Publication Date: 2022-12-30T17:49:15Z
• Authors: Kaiyu Liang; Chenchen Zhao; Chenxin Song; Lan Zhao; Pengcheng Qiu; Shengyu Wang; Jinjin Zhu; Zhe Gong; Zhaoming Liu; Ruikang Tang; Xiangqian Fang; Yueqi Zhao
• Keywords: Decellularization; Simulated body fluid; Bone tissue

A critical-sized bone defect, which cannot be repaired through self-healing, is a major challenge in clinical therapeutics. The combination of biomimetic hydrogels and nano-hydroxyapatite (nano-HAP) promising way to solve this problem by constructing an osteogenic microenvironment. However, it challenging generate nano-HAP with similar morphology structure that natural bone, limits the improvement regeneration hydrogels. Inspired our previous works on organic-inorganic cocross-linking, here, we built strong interaction cross-linking periosteum-decellularized extracellular matrix calcium phosphate oligomers, ensured situ mineralization bone-like resulting hydrogel (BOH) promotes mineralization, construction immune microenvironment, angiogenesis vitro. BOH exhibited acceleration osteogenesis vivo, achieving large-sized defect remodeling within 8 weeks, superior many previously reported This study demonstrates important role osteogenesis, deepens understanding design biomaterials for hard tissue repair. emphasizes advantages inorganic ionic oligomers interaction, provides alternative method preparation advanced materials.