Promotion of Wound Healing Using Nanoporous Silk Fibroin Sponges

• DOI: 10.1021/acsami.2c20274
• Publication Date: 2023-03-01T08:47:13Z
• Authors: Jian Liu; Xusheng Xie; Tao Wang; Hao Chen; Yuhang Fu; Xinyu Cheng; Jianbing Wu; Gang Li; Chenming Liu; Henrikki Liimatainen; Zhaozhu Zheng; Xiaoqin Wang; David L. Kaplan
• Keywords: Fibroin; Biocompatibility; Biomaterial; Sponge; Absorbance

Wound dressings are important for wound repair. The morphology of the biomaterials used in these dressings, and particular, pore structure affects tissue regeneration by facilitating attachment proliferation cells due to hierarchical multiscale, water absorbance, nutrient transport. In present study, silk fibroin (SF) sponges with walls containing nanopores (SFNS) were prepared from SF nanoparticles generated during autoclaving solutions, followed leaching freeze-dried SF. nano/microporous structure, biofluid porosity without characterized. vitro cell proliferation, vivo biocompatibility, healing evaluated sponges. results demonstrated that SFNS had significantly increased permeability, as well when compared (SFS). assessed a rat skin model, was superior SFS accelerating healing, supported vascularization, deposition collagen, epidermal thickness over 21 days. Hence, such dressing material multiscale could promote migration, independently adding any growth factor, which would offer new strategy design engineer better-performed dressing.