Photo-Activable Organosilver Nanosystem Facilitates Synergistic Cancer Theranostics
Photosensitizing Agents
Breast Neoplasms
02 engineering and technology
3. Good health
Photochemotherapy
Cell Line, Tumor
Tumor Microenvironment
Humans
Nanoparticles
Female
Precision Medicine
Reactive Oxygen Species
0210 nano-technology
DOI:
10.1021/acsami.2c21004
Publication Date:
2022-12-29T11:44:40Z
AUTHORS (11)
ABSTRACT
Anticancer drug development is important for human health, yet it remains a tremendous challenge. Photodynamic therapy (PDT), which induces cancer cell apoptosis via light-triggered production of reactive oxygen species, is a promising method. However, it has minimal efficacy in subcellular targeting, hypoxic microenvironments, and deep-seated malignancies. Here, we constructed a breast cancer photo-activable theranostic nanosystem through the rational design of a synthetic lysosomal-targeted molecule with multifunctions as aggregation-induced near-infrared (NIR) emission, a photosensitizer (PDT), and organosilver (chemotherapy) for NIR imaging and synergistic cancer therapy. The synthetic molecule could self-assemble into nanoparticles (TPIMBS NPs) and be stabilized with amphiphilic block copolymers for enhanced accumulation in tumor sites through passive targeting while reducing the leakage in normal tissues. Through photochemical internalization, TPIMBS NPs preferentially concentrated in the lysosomes of cancer cells and generated reactive oxygen species (ROS) upon light irradiation, resulting in lysosomal rupture and release of PSs to the cytosol, which led to cell apoptosis. Further, the photoinduced release of Ag+ from TPIMBS NPs could act as chemotherapy, significantly improving the overall therapeutic efficacy by synergistic effects with PDT. This research sheds fresh light on the creation of effective cancer treatments.
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CITATIONS (10)
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