Wearable Flexible Perspiration Biosensors Using Laser-Induced Graphene and Polymeric Tape Microfluidics

• DOI: 10.1021/acsami.3c04665
• Publication Date: 2023-08-01T15:08:29Z
• Authors: Nate T. Garland; Jacob Schmieder; Zachary T. Johnson; Robert G. Hjort; Bolin Chen; Cole Andersen; Delaney Sanborn; Gabriel Kjeldgaard; Cicero C. Pola; Jingzhe Li; Carmen Gomes; Emily A. Smith; Hector Angus; Jacob Meyer; Jonathan C. Claussen
• Keywords: Perspiration

Wearable biosensors promise real-time measurements of chemicals in human sweat, with the potential for dramatic improvements medical diagnostics and athletic performance through continuous metabolite electrolyte monitoring. However, sweat sensing is still its infancy, questions remain about whether can be used purposes. sensors are focused on proof-of-concept designs that not scalable multisubject trials, which could elucidate utility health Moreover, many wearable do include microfluidics necessary to protect channel consistent clean volumes sensor surface or designed disposable prevent biofouling inaccuracies due repeated use. Hence, there a need produce low-cost single-use integrated ensure reliable sensing. Herein, we demonstrate convergence laser-induced graphene (LIG) based soft tape polymeric quantify both metabolites (glucose lactate) electrolytes (sodium) hydration fatigue Distinct LIG-electrodes were functionalized glucose oxidase lactate selective across physiological ranges found sensitivities 26.2 2.47 × 10-3 μA mM-1 cm-2, detection limits 8 220 μM, linear response 0-1 mM 0-32 mM, respectively. sodium-ion-selective membrane displayed Nernstian sensitivity 58.8 mV decade-1 over range (10-100 mM). The tested simulated sweating skin microfluidic system on-body during cycling tests trial. Results LIG real-time, biological analytes help pave way development personalized diagnostic tools.