Doxorubicin-Loaded Liposome with the Function of “Killing Two Birds with One Stone” against Glioma

• DOI: 10.1021/acsami.3c10364
• Publication Date: 2023-10-02T17:46:52Z
• Authors: Juan Cen; Xiaoying Dai; Han Zhao; Xiaohan Li; Xiaojiao Hu; Jing Wu; Shaofeng Duan
• Keywords: Mice; Drug Delivery Systems; Brain Neoplasms; Doxorubicin; Blood-Brain Barrier; Cell Line, Tumor; Liposomes; Animals; Mice, Nude; Glioma; 3. Good health

The blood-brain barrier (BBB) continues to be one of the main clinical obstacles in treatment glioma. Current chemotherapies always bring many different side effects, some even permanent. To date, nanomaterial-based vehicles have shown great potential treating Herein, we developed a dual targeting liposomal delivery vector loaded with anticancer drug doxorubicin (DOX) treat SS31, small peptide, has effects penetrating BBB and specifically mitochondria. In this study, new system, LS-DOX, was prepared by modifying DOX-loaded liposomes SS31 for situ demonstrated high encapsulation rate drug-loading capacity, satisfactory biocompatibility, glioma accumulation ability, good stability vitro. Experimental results showed that could effectively cross target gliomas, mitochondria-targeting enhances cell uptake. addition, therapeutic effect on nude mice no obvious toxicity effects. Therefore, present research will provide novel alternative reference effective